SOX2 and neoplasm: Furthermore, the MYH9/GSK3β/β-catenin signal and its downstream tumor stemness and EMT effects were observed to be significantly attenuated in FOXO1-suppressed NPC cells treated with CB, which was accompanied by reduced N-Ca, Vimentin, OCT4, SOX2, and β-catenin protein levels and elevated E-Ca, GSK3β, and p-GSK3β protein levels (Fig. 5g, l).