Cancer stem-like cells in pancreatic ductal adenocarcinoma and gastric cancer cells are FOXO1-negative.9,10 In contrast, FOXO1 induces tumor stemness in glioblastoma.11 In previous studies, we reported that FOXO1 induces miR-3188 expression, which suppresses nasopharyngeal carcinoma(NPC) growth and 5-Fu chemoresistance.12 However, the role of FOXO1 in modulating NPC CSCs, metastatic ability, and cisplatin (DDP) resistance is still unclear. This evidence concerns the gene FOXO1 and nasopharyngeal carcinoma.