Altogether, our findings elucidate a complex molecular mechanism that involves FOXO1, MYH9, PI3K/AKT/c-Myc, p53, miR-133a-3p, ubiquitin, TRAF6, the GSK3β/Wnt/β-catenin/TCF4/ZEB1 pathway, miR-200b, tumor stemness, and EMT signals in NPC (Supplementary Fig. 6). Here, TCF4 is linked to nasopharyngeal carcinoma.