Furthermore, we found that suppression of PI3K by a specific inhibitor in si-FOXO1-treated FOXO1-overexpressing NPC cells reduced the activation of PI3K/AKT/c-Myc and the activation of MYH9, and it upregulated P53/miR-133a-3p signals. Here, AKT1 is linked to nasopharyngeal carcinoma.