Mutations in at least three different laminin chain genes result in junctional epidermolysis bullosa, Laminin Gamma 3 (LAMC2),14Laminin Alpha 3 (LAMA3),15Laminin Beta 3 (LAMB3)16,17 and cutis laxa.18 Mutations in Laminin Beta 2 (LAMB2) result in Pierson’s Syndrome.19Laminin alpha4 (LAMA4) mutations are associated with cardiomyopathy20 and mutations in LAMA2 cause congenital muscular dystrophy type 1A (MDC1A).21 Here, LAMA2 is linked to Congenital muscular dystrophy type 1A.