As P27Kip1 is a known downstream target of both CACYBP and RNF41, a previous study has described that CACYBP aids in the degradation of cytoplasmic P27Kip1 by Siah1 45, and RNF41 reduces the level of cytoplasmic P27Kip1via suppression of ERBB3-Akt signaling 46, thus causing effects on the migration and invasion abilities of glioma cells. Here, AKT1 is linked to central nervous system cancer.