In addition to SMYD2 expression (P = 0.000, HR = 7.974) and the ccRCC TNM stage (P = 0.000, HR = 7.974), the Fuhrman grade can also serve as an independent predictor of DFS in ccRCC patients (P = 0.023, HR = 2.236, Table 1). The gene discussed is SMYD2; the disease is nonpapillary renal cell carcinoma.