We screened 6 potentially downregulated tumor-activating miRNAs (miR-18a-3p, miR-2277-5p, miR-1293, miR-93-3p, miR-5706, and miR-125b) by overlapping the 18 downregulated miRNAs in the SMYD2-knockdown cells with the 97 upregulated miRNAs in the ccRCC samples (Fig 3B-C). The gene discussed is SMYD2; the disease is nonpapillary renal cell carcinoma.