IARS1 and nonpapillary renal cell carcinoma: The specific and representative IHC-staining intensity patterns for the SMYD2 protein in the ccRCC samples are shown in Figure 1D. The Kaplan-Meier survival analysis and log-rank test showed that the SMYD2 expression levels in renal cancer cells were significantly associated with a worse overall survival (OS; P = 0.0014) and DFS (P = 0.0279), based on the IRS (Figure 1E and 1F, respectively).