Besides ccRCC, abnormal expression and tumorigenic properties of SMYD2 have recently been reported in many tumors, including papillary thyroid carcinoma, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma and papillomavirus-unrelated non-multiple head and neck carcinomas 16-19, 33. Here, SMYD2 is linked to nonpapillary renal cell carcinoma.