Furthermore, ZBTB28 promoter methylation was detected in 87.5% (84/96) Lung, 100% (21/21) NPC, 67.5% (27/40) ESCC, 78.9% (30/38) GsCa, and 91.9% (34/37) colon primary tumors, but rarely in normal lung, nasal, esophagus, colon or gastric tissues (Figure 1D, Figure S1C,Figure S4). The gene discussed is BCL6B; the disease is esophageal squamous cell carcinoma.