RT-PCR analysis showed that ZBTB28 is expressed widely in normal adult and fetal tissues (Figure S1A), but silenced or frequently downregulated in 5/8 lung, 5/6 NPC, 15/18 ESCC, 11/16 GsCa, and 5/6 colon cancer cell lines (Figure 1B). The gene discussed is BCL6B; the disease is esophageal squamous cell carcinoma.