The genes deregulated in HCC treated with high-dose ascorbate belonged to five canonical signalling pathways that are frequently deregulated in cancer: Insulin Receptor Signalling, Dolichol and Dolichyl Phosphate Biosynthesis, UDP-N-acetyl-D-glucosamine Biosynthesis II, Ceramide Biosynthesis, and IL-3 Signalling Pathways (Table S3). This evidence concerns the gene INSR and cancer.