The increased expression of metabolic checkpoint enzyme arginase-1 (ARG1) and mannose receptor-1 (MRC1) are triggered by IL-4 treatment in M2-like signature (tumor supportive) while the higher expression of IL-12 and nitric oxide synthase (NOS2) is associated with M1-like (anti-tumor) signature, which may be induced by IFN-γ secretion. This evidence concerns the gene NOS2 and neoplasm.