In addition, the analysis of the impact of isoenzymes on patients’ survival rates should also take into account that both, PFKFB3 and PFKFB4 are vastly involved in other important biological processes in a non-glycolysis-dependent manner [13–16, 30–32], which could also explain their opposite effect on neuroblastoma patients’ prognosing. The gene discussed is PFKFB4; the disease is neuroblastoma.