Because IL-6 and IL-11 play catalytic roles in colorectal cancer27-29 and many other tumors18, 30-32, and IL-133, IL-11β34, IL-235 IL-436, IL-635-37, and IL-1138 have been confirmed to be resistant to radiotherapy, we identified that alterations in IL-6 and IL-11 expression were involved in the irradiation resistance of CRC cells in vitro as the downstream effectors of MTERFD1. The gene discussed is MTERF3; the disease is colorectal carcinoma.