PLAU and neoplasm: Increasing VASP expression in NIH3T3 fibroblasts may cause a tumorigenic phenotype 20, VASP silencing downregulated Migfilin, β-catenin and urokinase plasminogen activator, inhibited tumor spheroid invasion in MDA-MB-231 cells, and phosphorylation of VASP has been suggested as a marker for the potential of metastatic progression of prostate and breast tumors 21, 22.