In this study, we continue to explore the important role of the key oncogene VASP in the development of breast cancer, and explain the mechanism of the CREB1/Lin28/miR-638/VASP interactive network to promote the development of breast cancer, which further elucidate the mechanism of VASP as a key oncogene, and also provide a theoretical basis for expanding new approaches to tumor biotherapy. Here, CREB1 is linked to breast carcinoma.