Phenotypically, TYR-KO Tibet minipigs exhibited the typical features of albinism (Figure 4A), including red-coloured eyes with light pink-tinted irises (Figure 4B, C) and no pigmentation in the skin (Figure 4B, D), in contrast to the dark irises and black skin of wild-type Tibet minipigs (Figure 4A-D). The gene discussed is TYR; the disease is albinism.