In addition, we obtained dual gene knockout piglets [i.e., c9 (TYR-/-IL2RG-/-), d14 (TYR-/-RAG1-/-) and d15 (TYR-/-RAG1-/-)] had phenotypes of both albinism and immunodeficiency, whereas some chimeras (i.e., piglet c12 carrying the TYR and IL2RG mutations) had the albino phenotype but did not exhibit immunodeficiency (Table 3). The gene discussed is IL2RG; the disease is immunodeficiency disease.