In addition, we obtained dual gene knockout piglets [i.e., c9 (TYR-/-IL2RG-/-), d14 (TYR-/-RAG1-/-) and d15 (TYR-/-RAG1-/-)] had phenotypes of both albinism and immunodeficiency, whereas some chimeras (i.e., piglet c12 carrying the TYR and IL2RG mutations) had the albino phenotype but did not exhibit immunodeficiency (Table 3). This evidence concerns the gene TYR and immune system disorder.