As showed in Fig 8B, p53 expression was reduced into half of the amount in tumor tissue compared with the control, and a slightly increased of p53 level in the aged mitochondrial group compared with tumor group, but a remarkable increasing in young mitochondria group (Fig 8B), suggesting that young mitochondria have the ability to recover the p53 level while aged mitochondria with functional deficiency could not increase the level of p53 back to normal. This evidence concerns the gene TP53 and neoplasm.