Considering the research findings of LEE that the depletion of RMP increases CDDP-induced apoptosis in ovarian cancer cells by activating mitochondrial S6K1-BAD signaling pathway 32, we suspect that the knock-down of RMP in HCC might probably involve the activation of pro-apoptotic family members such as BAD/BAX. The gene discussed is URI1; the disease is hepatocellular carcinoma.