Consistently, the results showed that the expression levels of TNFA, S100A8, and NLRP1 were significantly upregulated (Figures 4B-4D), while the expression levels of CDH1, GLTPD and PSRC1 were dramatically downregulated in lung tissues from ALI patients compared to those from controls (Figures 4E-4G). This evidence concerns the gene S100A8 and acute respiratory distress syndrome.