The CtBP1-p300-FOXO3a complex can specifically repress the expression of two downstream targets, Bax and Bim, but not other known CtBP1 targets such as CDH1 (epithelial Cadherin), PTEN (Phosphatase and Tensin Homolog), and CDKN1A (Cyclin-Dependent Kinase Inhibitor 1A) in human osteosarcoma cells 44. This evidence concerns the gene FOXO3 and osteosarcoma.