Importantly, multivariate analysis confirmed that lower PHKB expression was an independent prognostic predictor for shorter OS (Table 3; RR=2.083, 95%CI=1.449-4.808, P=0.002) and TTR (Table 3; RR=1.934, 95%CI=1.239-3.012, P=0.004) in HCC patients. The gene discussed is PHKB; the disease is hepatocellular carcinoma.