CMTM4 and non-small cell lung carcinoma: Mezzadra also transfected the NSCLC cell line H2030 with short hairpin (sh)RNA against CMTM6, either exclusively or in combination with shRNA against CMTM4, and found out that while the absence of CMTM6 decreased PD-L1, CMTM4 could attenuate this effect 26.