Surprisingly, elevated L1CAM expression in GC tissues was an independent predictive factor for lymph node metastasis (OR, 4.11; 95% CI, 1.03–16.4; p = 0.045, Table 3c) and distant metastasis (OR, 5.47; 95% CI, 1.66–18.1; p = 0.005, Table 3d) in GC tissues. This evidence concerns the gene L1CAM and metastatic malignant neoplasm in the lymph nodes.