L1CAM and gastric cancer: Anoikis is currently recognised as an apoptotic process by loss of cell adhesion,21 and therefore, anoikis resistance is involved in the metastatic process.22 Our clinical findings revealed that L1CAM overexpression was an independent risk factor for distant metastasis; therefore, we hypothesised that L1CAM has the function of resistance to anoikis in GC cells.