Several evidences have demonstrated L1CAM as an oncogenic driver in various types of cancer.32–34 Hai and colleagues used short-hairpin RNA to show that inhibition of L1CAM expression significantly suppressed invasiveness and tumorigenicity of lung cancer cells via the extracellular signal-regulated kinase pathway.32 Consistent with these findings, we revealed that L1CAM knockdown inhibited various oncogenic phenotypes related to the metastatic process, including proliferation, cycle progress, invasion, migration, and anoikis resistance in GC cell lines. This evidence concerns the gene L1CAM and gastric cancer.