Compared with the osteoporosis-related database37, 33 genes belonged to the osteoporosis-related gene family and 11 genes had been reported as osteoporosis-related genes (ADAM17, ALOX12B, CAMKK2, ELN, HAMP, MITF, PTPN1, SOCS3, TNFSF11, VHL, VPS35). The gene discussed is ALOX12B; the disease is osteoporosis.