CDK1 and hepatocellular carcinoma: Regarding CCNB2 and CDK1, a recent study with primary HCC tissue samples showed that the downregulation of CCNB2 and CDK1 led to the inhibition of cell proliferation and cell cycle shutdown in the G2/M phase, indicating that the overexpression of CCNB2/CDK1 may promote tumour cell proliferation14.