With the application of the Cytoscape app cytoHubba, the top ten hub genes contributing to HCC were predicted and are as follows: ASPM, MELK, CCNB1, NDC80, BUB1B, NCAPG, CDK1, NUSAP1, CCNB2 and TPX2. This evidence concerns the gene TPX2 and hepatocellular carcinoma.