These results indicate that subjects with the minor TT genotype at rs1256328 (ALPL) or the minor AA genotype at rs12654812 (RGS14) had higher susceptibility to nephrolithiasis, compared to those with major alleles in these two SNPs (C allele at rs1256328 (ALPL) or G allele at rs12654812 (RGS14)). This evidence concerns the gene RGS14 and nephrolithiasis.