Confirming our previous experiments, L.g.+ infection induced increased ear thickness compared with L.g.− in C57BL/6 (Fig. 8a and Supplementary Fig. 8a), but not in Nlrp3−/− (Fig. 8b), Asc−/− (Supplementary Fig. 8b), Casp1−/− (Supplementary Fig. 8c) or Tlr3−/− (Supplementary Fig. 8d) mice. The gene discussed is TLR3; the disease is infection.