To further investigate the LRV-inhibition of the NLRP3 inflammasome in human cells, we measured IL-1β and Casp1 p20 in response to L.g.− and L.g.+ infection in cells treated with KCl (which impairs potassium efflux and activation of NLRP3) or Poly:IC (TLR3 agonist). The gene discussed is CASP1; the disease is infection.