TNC and central nervous system cancer: TNC was significantly upregulated in high-grade glioma rather than in low-grade glioma (Fig. 1a and Supplementary Table 1) and was significantly correlated with a poor prognosis (p < 0.0001, Fig. 1b), concurrent with the results of the Sun Brain Statistics cohort in the ONCOMINE database showing the upregulation of TNC mRNA with an increase in glioma grade (Fig. 1c).