LGR5 and glioblastoma: Among the top 20 most upregulated genes in the JQ1-sensitive class of GBM cells, we identified OLIG2 and LGR5. OLIG2 is known marker of proneural GBM subtype5 and ectopic expression of OLIG2 together with other neurodevelopmental transcription factors can induce pluripotency in differentiated GBM cells45.