Corresponding to the in vivo results, WDR5 silencing led to a consistent reduction of MDA-MB-231 in vitro FBS-directed cell migration (Additional file 1: Figure S5D), wound healing (Additional file 1: Figure S5E), and random migration assays (Additional file 1: Figure S5F), confirming that WDR5 impacts on the ability of BC cells to migrate and metastasize to distant organs and that its expression is predictive of metastatic disease. Here, WDR5 is linked to metastatic neoplasm.