Moreover, WDR5 binds the mesenchymal gene promoter and transcriptionally regulates N-cadherin in BC upon hypoxia treatment [28], ZNF407 in colorectal cancer [23], HOXA9 in prostate cancer [22], and SNAIL1 and VIMENTIN in lung tumor cells [9], leading to EMT. Here, SNAI1 is linked to breast cancer.