GEPIA bioinformatics analysis showed that CD147, Rac1 and an Arf6-specific GEF ARNO exhibited higher transcription levels in liver cancer tissues than in matched normal liver tissues (Fig. 6a, g, m), whereas, the mRNA level of Arf6 and other Arf6-specific GEFs or GAPs (except ACAP3) tended to be no different (Fig. 6d and Additional file 1: Figure S6). Here, ACAP3 is linked to liver cancer.