Although CD147 and Arf6 significant expression in liver cancer were already reported [5, 7, 8, 10, 48, 55, 56], we found for the first time that expression of the CD147-assocaited Arf6-ARNO-Rac1 signal axis in liver cancer tissues was significantly higher than in surrounding non-tumorous tissues (Fig. 6a-m, and Fig. 7a, b). This evidence concerns the gene RAC1 and liver cancer.