ARF6 and hepatocellular carcinoma: Markedly, high expression of Arf6-CD147 signaling components was significantly correlated with more aggressive characters, in terms of advanced TNM stage, portal vein tumor thrombus, high AFP level, and short overall survival, which are putative clinicopathological markers for HCC development, invasiveness, and unfavorable prognosis (Fig. 7c-k, Table.