ACTA2 and hypertensive disorder: Medications that reduce hemodynamic stress, such as β-blockers, should be considered in ACTA2 patients, with aortic dilatation (aortic diameter at z-score ≥ 2) or hypertension or progression of aortic dilatation (> 0,3 cm/year) and is reasonable to propose in ACTA2 patients without dilatation.