In this process, EZH2 silences anti-proliferative genes, including CDKN family cell cycle-related tumor suppressors (CDKN1A, CDKN1B, and CDKN2A) [26, 27], through the conferment of H3K27 tri-methylation marks, and helps establish bivalent chromatin at key regulatory loci to transiently repress GC B cell differentiation [28], making provisions for antibody diversification, affinity maturation [29], and secretion [30]. This evidence concerns the gene EZH2 and neoplasm.