TIS21 was shown to induce the translocation of AKT1 and pAKT1 to the nucleus, resulting in detection of AKT1 and pAKT1 in cytoplasm and nucleus [152], whereas Plant et al. reported a shift of AKT1 staining from nucleus to cytoplasm during breast cancer progression [196]. The gene discussed is AKT1; the disease is breast carcinoma.