However, Gd-IgA1 pathway is probably involved, due to the presence of similar manifestation in other IgA related disorders, such as IgA nephropathy (IgAN), ANCA-associated vasculitis overlap syndrome, IgA-dominant post-infectious glomerulonephritis, IgA-variant Goodpasture’s syndrome and IgA-producing monoclonal gammopathy [40–42]. The gene discussed is IGHA1; the disease is IgA glomerulonephritis.