CDH2 and Hemoglobin C Measurement: To determine if the lncRNA-HGBC-induced AKT activation is dependent on participation of miR-502-3p, we used miR-502-3p binding mutation of lncRNA-HGBC and found that lncRNA-HGBC overexpression in GSC-SD and EH-GB1 cells led to increases in AKT phosphorylation, N-cadherin, and vimentin, whereas lncRNA-HGBC MUT failed to induce these protein levels (Fig. 7c).