Among healthy subjects from Spain, the frequency (8.8%) and MAF (4.2%) of the BAFF-var allele were increased; however, among the corresponding Spanish SLE cohort the prevalence and MAF of the BAFF-var allele were even higher than in healthy control subjects with 10.8 and 5.81%, respectively [19]. This evidence concerns the gene TNFSF13B and systemic lupus erythematosus.