With regard to diverse manifestations of SLE at the time of study entry, a biopsy proven lupus nephritis developed in 10 of the 18 patients (56%) with the BAFF-var allele and in 61 of the 177 patients (34%) who did not carry this allele (p = 0.038; OR [odds ratio], 2.4; 95% confidence interval [CI], 0.89–6.34) (Table 2). This evidence concerns the gene TNFSF13B and systemic lupus erythematosus.