When the primary tumor possessed Nrf2 gene mutations, the C/A or A/A genotypes of rs6721961, or elevated Nrf2 protein expression, metastatic lesions demonstrated a worse response to VEGF-targeting therapy (p = 0.0142, p = 0.0018, and p < 0.0001, respectively) (Table 3). Here, NFE2L2 is linked to neoplasm.