For example, AKT1 is experimentally found therapeutic target gene [34], CD44 is found to be target gene, which serve as the backbone for paclitaxel prodrugs [41], MCAM is reported to be an important metastasis marker and invasion of ovarian cancer cells [42], KRAS is identified as important genetic marker of ovarian cancer [43]. This evidence concerns the gene KRAS and ovarian carcinoma.