However, patients who belong to the medium HCC recurrence risk category (e.g. single nodule, diameter of 8 cm and serum AFP of 700 ng/mL), a careful selection for LT based on a personalized assessment and pre-LT downstaging therapy should be considered then early administration of mTOR inhibitor postoperatively are strongly recommended [34]. The gene discussed is MTOR; the disease is hepatocellular carcinoma.