While for 185 patients who are exceeding AFP model (38.1%), the risk of 2-year HCC recurrence was 9.8% (95% CI: 0.02–0.39),20.8% (95% CI: 0.11–0.41), and 51.4%(95% CI: 0.36–0.73), respectively (overall p = 0.006) (Fig. 4c). This evidence concerns the gene AFP and hepatocellular carcinoma.