The role of a common non-synonymous polymorphism in transmembrane 6 superfamily member 2 (rs58542926 c.449 C > T, p.Glu167Lys, E167K) in lipid metabolism and chronic liver disease has attracted attention, with multiple studies focused on the role of TM6SF2 rs58542926 variant in chronic liver disease and HCC [6, 7]. The gene discussed is TM6SF2; the disease is hepatocellular carcinoma.