Although little is known on the effects of CKD on fatty acid metabolism, it has been demonstrated that curcumin decreased lipid accumulation by up-regulating PPARα while down-regulating various lipogenic genes such as SREBP1c, acetyl-CoA carboxylase 1 (ACC1), fatty acid synthase in the liver of mice [97, 98]. This evidence concerns the gene PPARA and chronic kidney disease.