In 2017, Zhao et al. [36] present a review on lncRNA involved in liver metabolism and cholestatic liver disease in which lncLSTR, Lnc18q22.2, SRA1, HULC, MALAT1, lncHR1 were related to the lipid metabolism and lnc-HC, APOA1-AS, H19, MEG3, lincRNA-DYNLRB2–2, LeXis involved in cholestatic liver pathologies. This evidence concerns the gene MEG3 and Cholestatic liver disease.