However, the IHC analysis also showed that 6 (6.25%) pADC samples and 2 (2.50%) pSCC were highly expressed of both Krt5 and Agr2 proteins, and 12 (12.50%) pADC and 13 (16.25%) pSCC samples were low expressed of both Krt5 and Agr2 proteins, suggesting the limitation of IHC of immunomarkers in distinguishing ADC from SCC. The gene discussed is KRT5; the disease is AIDS dementia complex.