Furthermore, miR-1/206 significantly reduces the expression of PAX3 protein in the ERMS cell line; however, it has not shown any effect on PAX3 protein levels in an ARMS cell line, suggesting that the PAX3-FOXO1 fusion gene present in ARMS might obstruct the regulation of PAX3 by those specific miRNAs [55]. This evidence concerns the gene FOXO1 and embryonal rhabdomyosarcoma.