Interestingly, genes related to sinusoidal endothelial dysfunction, activation of HSCs, and fibrosis development, such as platelet-derived growth factor receptor-α (PDGFRα), PDGFRβ, transforming growth factor-β1 (TGF-β1), and endothelin-1 (ET-1), were upregulated in both WT and TGR5 KO mice following LCA feeding. Here, EDN1 is linked to Leber congenital amaurosis.