S100A8 and gastric cancer: In a recent meta-analysis, CagA with a single EPIYA-D motif was significantly associated with a 1.91 fold increased gastric cancer risk in Asia compared with one EPIYA-C motif, and the CagA with two or more EPIYA-C motifs (EPIYA-A, -B, -C, -C or EPIYA-A, -B, -C, -C, -C) was associated with a significantly higher risk for PUDs in Asian countries and gastric cancer (OR (odd ratio) = 3.28) in the US and Europe [158].