In multivariable stepwise Model 2, after adjusting for hemoglobin A1c and significant variables in the univariable analysis (Table 2) except for fasting glucose, old age, a history of coronary artery disease, stroke and peripheral artery disease, a high TyG index (HR, 1.521; 95% CI, 1.141 to 2.027; p = 0.004), high UACR, and the use of anti-hypertensive drugs, aspirin, and insulin were independently associated with increased CV events. The gene discussed is INS; the disease is Stroke.