pS14-WWOX7-21 peptide failed to block melanoma cell metastasis and yet induced significant upregulation of the expansion of spleen helper CD4+ T cells (2-fold increase), cytotoxic CD8α+ T cells (25-fold increase) and CD19+ B cells (14-fold increase) in the germinal centers (Figure 3B,C). The gene discussed is CD8A; the disease is melanoma.