GPER is widely expressed in adipose tissue and both male and female GPER-deficient mice are obese with substantial increases in visceral, subcutaneous, and perivascular fat, whereas female GPER KO mice become glucose-intolerant by six months of age, with increased triglyceride levels and hepatic steatosis (reviewed in [7]). This evidence concerns the gene GPER1 and Hepatic steatosis.