A large, recent US retrospective study analyzed the predisposing factors for the evolution of liver injury and the occurrence of ESLD in 3573 HIV/CHB patients, and demonstrated that a low CD4+ count (CD4+ < 200/mmc aHR = 1.58 [CI 95% 1.36–4.91] and CD4+ 201–499/mmc, aHR 1.75 [CI 95% 1.04–2.39] vs. CD4+ > 500/mmc) and higher FIB-4 at the start of follow-up (>3.25: aHR = 9.79 [CI 95% 5.73–16.74]; 1.45–3.25: aHR = 3.20 [CI 95% 1.87–5.47] vs. FIB-4 < 1.45), in addition to diabetes and non-black/non-Hispanic race, were factors associated with an increased risk of liver disease progression. Here, CD4 is linked to liver disorder.