TNF and inflammatory bowel disease: In the inflamed colon tissues of IBD patients, rat experimental colitis, or TNFα triggered HT-29 colonic epithelial cells, the same reciprocal expression pattern was observed: increased NOTCH2 (Figure 3e,h) level was accompanied by downregulation of miR-30a (Figure 3f,i), miR-34,and miR-107 [37,88].