MMP2 and retinoblastoma: In experimental studies, it was shown that the MMP-2 and MMP-9 inhibitors ARP100 and AG-L-66085 significantly reduced migration via different mechanisms: ARP100 inhibited MMP-2 and subsequent transforming growth factor β1 (TGF-β1) secretion, whereas AG-L-66085 diminished the angiogenesis response by reducing vascular epithelial growth factor (VEGF) in a retinoblastoma model [99].