Considering the role of collagenases (MMP-8) and matrilysins (MMP-7, MMP-26) in the pathophysiology of ischemic stroke and only few epidemiology study investigate the association of genetic variants from collagenases and matrilysins with ischemic stroke, the purpose of this study is to investigate the effect of weighted genetic risk score (wGRS) from MMP-7, MMP-8 and MMP-26 on the risk of ischemic stroke. The gene discussed is MMP8; the disease is ischemic stroke.