In a rat model of GBM (C6 cells), using pharmacological modulators of HSP70 that control its intracellular levels and its capacity to bind with clients, researchers were able to demonstrate that intracellular HSP70 physically interacts with oxidized, inactive GAPDH in a dose-dependent manner, mainly through its chaperone activity, preventing its aggregation [74]. This evidence concerns the gene GAPDH and glioblastoma.