eHSP90 interaction with the co-receptor LRP1 (low density lipoprotein receptor-related protein 1) modulates AKT phosphorylation on S897 residue of ephrin A2 (p-EphA2S897), sustaining AKT signaling and lamellipodia formation, and, consequently, increasing GBM cell motility and invasion, which are further enhanced by hypoxia [62]. The gene discussed is AKT1; the disease is glioblastoma.