Comincini et al. analyzed and compared the expression of PrPC and Dpl in tissue samples obtained from more than 100 astrocytomas encompassing both low and high grade glioma cell lines, as well as other malignancies (anaplastic meningiomas and gastric adenocarcinomas), using adult and fetal normal cortical tissues as controls [136,199]. This evidence concerns the gene PRNP and glioma.