PRNP and glioblastoma: Of therapeutic relevance, Martin’s group, reported that the formation of PrPC/STI1 complexes induces proliferation of GBM cell lines, via the activation of PI3K and ERK1/2, conversely the blockade of this interaction, depleting PrPC or using a STI1-derived peptide mimicking PrPC-interacting sequence which prevents the binding, inhibited cell growth [153].